High-quality IL-7 cytokines and receptors for R&D

Interleukin-7 (IL-7) is a cytokine that is essential to the development of T and B cell development. Immature immune cell arrest is caused as a result of a lack of IL-7. Several disorders, including HIV infections, chronic infections, cancer, and aging, are being treated with therapies that target IL-7 due to its crucial involvement in immunity and the pathogenesis of cancer.

The IL-2 cytokine superfamily, which also contains IL-2, IL-4, IL-9, IL-15, and IL-21, covers IL-7. To induce the Jak/STAT signaling cascade, IL7 binds to the common gamma chain receptor (ɣc/IL2RG) along with the receptor for IL-7, IL7RA/CD127.

Additionally, IL7R is activated by thymic stromal lymphopoietin (TSLP), which then forms a heterodimer with the TSLP receptor (TSLPR/CRLF2). TSLP signaling is also essential in influencing lymphocyte fate and function. To aid in the study of this cytokine family, Sino Biological has created a panel of premium recombinant IL-7 and receptors.

Recombinant IL-7 & Receptor Proteins

From various species, such as humans, mice, cynomolgus, and rat, Sino Biological has produced high-quality recombinant IL-7 and receptor proteins.

Featured IL-7 & Receptor Proteins

Human IL-7 Protein Cat#: 11821-HNAE

High-quality IL-7 cytokines and receptors for R&D

Purity: ≥95% as determined by SDS-PAGE & HPLC. Image Credit: Sino Biological Inc.

High-quality IL-7 cytokines and receptors for R&D

Cell proliferation assay using anti-CD3 antibody activated human peripheral blood mononuclear cell. Image Credit: Sino Biological Inc.

Human IL-7Rα Protein Cat#: 10975-H02H

High-quality IL-7 cytokines and receptors for R&D

Immobilized IL-7 Protein (Cat#: 11821-HNAE) can bind IL-7RA. Image Credit: Sino Biological Inc.

Product List of Recombinant IL-7 & Receptors

Table 1. Source: Sino Biological Inc.

Cat#MoleculeSpeciesExpressed HostPurityActivityTag
50217-MNAEIL7MouseE. coli> 90%ActiveNative
10975-H08HIL7RHumanHEK293 Cells> 92%ActiveC-His
50090-M08HIL7RMouseHEK293 Cells> 85% C-His
80083-R08HIL7RRatHEK293 Cells> 95% C-His
CT114-H08HIL7RA & IL2RGHumanHEK293 Cells> 95% C-His

 

Other Related Proteins

  • IL7RA/CD127
  • IL-2
  • IL-15
  • TSLPR/CRLF2
  • IL-9
  • IL2RG
  • IL-21
  • TSLP
  • IL-4

Antibodies for IL-7 & Receptors

A panel of IL-7-targeting antibodies has been created by Sino Biological and this panel can be utilized in ELISA, WB, FCM, and IHC procedures.

Anti-IL7R alpha Antibody, Rabbit MAb Cat#: 10975-R001

High-quality IL-7 cytokines and receptors for R&D

Flow cytometric analysis of Human IL-7RA expression on human whole blood lymphocytes. Image Credit: Sino Biological Inc.

High-quality IL-7 cytokines and receptors for R&D

Flow cytometric analysis of Human IL-7RA expression on human whole blood lymphocytes. Image Credit: Sino Biological Inc.

High-quality IL-7 cytokines and receptors for R&D

Immunochemical staining of mouse IL-7RA in mouse testis with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. Image Credit: Sino Biological Inc.